Sensorimotor processing for balance in spinocerebellar ataxia type 6.

We investigated whether balance impairments caused by cerebellar disease are associated with specific sensorimotor processing deficits that generalize across all sensory modalities. Experiments focused on the putative cerebellar functions of scaling and coordinate transformation of balance responses evoked by stimulation of single sensory channels. Vestibular, visual, and proprioceptive sensory channels were stimulated in isolation using galvanic vestibular stimulation, moving visual scenery, and muscle vibration, respectively, in 16 subjects with spinocerebellar ataxia type 6 (SCA6) and 16 matched healthy controls. Two polarities of each stimulus type evoked postural responses of similar form in the forward and backward directions. Disease severity was assessed using the Scale for Assessment and Rating of Ataxia. Impaired balance of SCA6 subjects during unperturbed stance was reflected in faster than normal body sway (P = 0.009), which correlated with disease severity (r = 0.705, P < 0.001). Sensory perturbations revealed a sensorimotor processing abnormality that was specific to response scaling for the visual channel. This manifested as visually evoked postural responses that were approximately three times larger than normal (backward, P < 0.001; forward P = 0.005) and correlated with disease severity (r = 0.543, P = 0.03). Response direction and habituation properties were no different from controls for all three sensory modalities. Cerebellar degeneration disturbs the scaling of postural responses evoked by visual motion, possibly through disinhibition of extracerebellar visuomotor centers. The excessively high gain of the visuomotor channel without compensatory decreases in gains of other sensorimotor channels provides a potential mechanism for instability of the balance control system in cerebellar disease. © 2015 International Parkinson and Movement Disorder Society

Reactor Fuel Fraction Information on the Antineutrino Anomaly

We analyzed the evolution data of the Daya Bay reactor neutrino experiment in terms of short-baseline active-sterile neutrino oscillations taking into account the theoretical uncertainties of the reactor antineutrino fluxes. We found that oscillations are disfavored at $2.6\sigma$ with respect to a suppression of the $^{235}\text{U}$ reactor antineutrino flux and at $2.5\sigma$ with respect to variations of the $^{235}\text{U}$ and $^{239}\text{Pu}$ fluxes. On the other hand, the analysis of the rates of the short-baseline reactor neutrino experiments favor active-sterile neutrino oscillations and disfavor the suppression of the $^{235}\text{U}$ flux at $3.1\sigma$ and variations of the $^{235}\text{U}$ and $^{239}\text{Pu}$ fluxes at $2.8\sigma$. We also found that both the Daya Bay evolution data and the global rate data are well-fitted with composite hypotheses including variations of the $^{235}\text{U}$ or $^{239}\text{Pu}$ fluxes in addition to active-sterile neutrino oscillations. A combined analysis of the Daya Bay evolution data and the global rate data shows a slight preference for oscillations with respect to variations of the $^{235}\text{U}$ and $^{239}\text{Pu}$ fluxes. However, the best fits of the combined data are given by the composite models, with a preference for the model with an enhancement of the $^{239}\text{Pu}$ flux and relatively large oscillations.Comment: 9 page

Episodic ataxias: Faux or real?

The term Episodic Ataxias (EA) was originally used for a few autosomal dominant diseases, characterized by attacks of cerebellar dysfunction of variable duration and frequency, often accompanied by other ictal and interictal signs. The original group subsequently grew to include other very rare EAs, frequently reported in single families, for some of which no responsible gene was found. The clinical spectrum of these diseases has been enormously amplified over time. In addition, episodes of ataxia have been described as phenotypic variants in the context of several different disorders. The whole group is somewhat confused, since a strong evidence linking the mutation to a given phenotype has not always been established. In this review we will collect and examine all instances of ataxia episodes reported so far, emphasizing those for which the pathophysiology and the clinical spectrum is best defined

Mitochondrial Dysfunction in Friedreich Ataxia

Friedreich’s Ataxia (FRDA) is the commonest hereditary form of ataxia affecting the Western European population. FRDA is an autosomal recessive neurodegenerative disorder caused by an intronic GAA repeat expansion within the FXN gene; the 96% of the patients are homozygous, while the remaining 4% are compound heterozygous carrying the GAA repeat mutation on one allele and point mutations on the other one. FRDA first symptoms appear at young age during the firsts two decades of life. The clinical features include progressive gait and limb ataxia, dysarthria, muscle weakness, peripheral sensory neuropathy, pes cavus, and scoliosis. FRDA is a multi-systemic disorder; therefore, patients develop non-neurological signs, such as hypertrophic cardiomyopathy, diabetes, and urological problems

Gopi: compiling linear and static channels in go

PTDC/CCI-COM/32166/2017We identify two important features to enhance the design of communication protocols specified in the pi-calculus, that are linear and static channels, and present a compiler, named GoPi, that maps high level specifications into executable Go programs. Channels declared as linear are deadlock-free, while the scope of static channels, which are bound by a hide declaration, does not enlarge at runtime; this is enforced statically by means of type inference, while specifications do not include annotations. Well-behaved processes are transformed into Go code that supports non-deterministic synchronizations and race-freedom. We sketch two main examples involving protection against message forwarding, and forward secrecy, and discuss the features of the tool, and the generated code. We argue that GoPi can support academic activities involving process algebras and formal models, which range from the analysis and testing of concurrent processes for research purposes to teaching formal languages and concurrent systems.publishersversionpublishe

Probing Sterile Neutrino Parameters with Double Chooz, Daya Bay and RENO

In this work, we present a realistic analysis of the potential of the present-day reactor experiments Double Chooz, Daya Bay and RENO for probing the existence of sterile neutrinos. We present exclusion regions for sterile oscillation parameters for each of these experiments, using simulations with realistic estimates of systematic errors and detector resolutions, and compare the sterile parameter sensitivity regions we obtain with the existing bounds from other reactor experiments. We find that these experimental set-ups give significant bounds on the parameter \Theta_{ee} especially in the low sterile oscillation region 0.01 < \Delta m_{41}^2 < 0.05 eV^2. These bounds can add to our understanding of the sterile neutrino sector since there is still a tension in the allowed regions from different experiments for sterile parameters.Comment: 12 pages, 5 figure

What can the SNO Neutral Current Rate teach us about the Solar Neutrino Anomaly

We investigate how the anticipated neutral current rate from $SNO$ will sharpen our understanding of the solar neutrino anomaly. Quantitative analyses are performed with representative values of this rate in the expected range of $0.8 - 1.2$. This would provide a $5 - 10 \sigma$ signal for $\nu_e$ transition into a state containing an active neutrino component. Assuming this state to be purely active one can estimate both the $^8B$ neutrino flux and the $\nu_e$ survival probability to a much higher precision than currently possible. Finally the measured value of the $NC$ rate will have profound implications for the mass and mixing parameters of the solar neutrino oscillation solution.Comment: Brief discussion on the first NC result from SNO added; final version to be published in the MPL

nu_e Disappearance in MiniBooNE

The anomalous excess of low-energy nu_e events measured in the MiniBooNE experiment is explained through a renormalization of the absolute neutrino flux and a simultaneous disappearance of the nu_e's in the beam, which is compatible with that indicated by the results of Gallium radioactive source experiments. We present the results of the fit of MiniBooNE data (P(nu_e->nu_e) = 0.64 +0.08 -0.07) and the combined fit of MiniBooNE data and the nu_e disappearance measured in the Gallium radioactive source experiments, which gives P(nu_e->nu_e) = 0.82 +- 0.04. We show that our interpretation of the data is also compatible with an old indication in favor of nu_e disappearance found from the analysis of the results of beam-dump experiments, leading to P(nu_e->nu_e) = 0.80 +0.03 -0.04.Comment: 17 pages. Final version published in Phys. Rev. D 77, 093002 (2008

Light sterile neutrino production in the early universe with dynamical neutrino asymmetries

Light sterile neutrinos mixing with the active ones have been recently proposed to solve different anomalies observed in short-baseline oscillation experiments. These neutrinos can also be produced by oscillations of the active neutrinos in the early universe, leaving possible traces on different cosmological observables. Here we perform an updated study of the neutrino kinetic equations in (3+1) and (2+1) oscillation schemes, dynamically evolving primordial asymmetries of active neutrinos and taking into account for the first time CP-violation effects. In the absence of neutrino asymmetries, eV-mass scale sterile neutrinos would be completely thermalized creating a tension with respect to the CMB, LSS and BBN data. In the past literature, active neutrino asymmetries have been invoked as a way to inhibit the sterile neutrino production via the in-medium suppression of the sterile-active mixing angle. However, neutrino asymmetries also permit a resonant sterile neutrino production. We find that if the active species have equal asymmetries L, a value |L|=10^{-3} is required to start suppressing the resonant sterile production, roughly an order of magnitude larger than what previously expected. When active species have opposite asymmetries the sterile abundance is further enhanced, requiring an even larger |L|\simeq 10^{-2} to start suppressing their production. In the latter case, CP-violation (naturally expected) further exacerbates the phenomenon. Some consequences for cosmological observables are briefly discussed: for example, it is likely that moderate suppressions of the sterile species production are associated with significant spectral distortions of the active neutrino species, with potentially interesting phenomenological consequences especially for BBN.Comment: (v2: 22 pages, 10 eps figures. Revised version. Typos removed, reference updated. Matches the version published on PRD.